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Dr. D. Bahulayan

Professor 

Senior Scientist, Energy Research Institute

Nanyang Technological University, Singapore


Phone (Off): +91 4942407413
Email: <This email address is being protected from spambots. You need JavaScript enabled to view it.>
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Office    : Department of Chemistry,
University of Calicut
 
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Education

Ph.D.: University of Kerala (1997)

M.Sc.: University of Kerala (1990)

Positions Held

  1. Senior Scientist, Energy Research Institute at Nanyang Technological University (ERI@N), Singapore; September 2015- till date (On leave from Calicut University)
  2. Administrator - Graduate Studies, Energy Research Institute at Nanyang Technological University (ERI@N), Singapore; March 2020- till date
  3. Professor, Department of Chemistry, University of Calicut; June 2014-till date
  4. Associate Professor, Department of Chemistry, University of Calicut; June 2010-June 2014
  5. Reader, Department of Chemistry, University of Calicut; September 2004- June 2010
  6. Co-ordinator, Department of Environmental Studies, University of Calicut, 2009-2012.
  7. Chairman, Board of Studies, Environmental Science and Water Management, University of Calicut, 2010-2012.
  8. Member, Board of Studies, Pharmaceutical Chemistry, University of Calicut, 2009-2013.
  9. Member, Faculty of Science, University of Calicut, 2011-2012.
  1. Member, “Erudite Scholar in residence” programme committee, University of Calicut, 2010-2012.
  2. Post-doctoral Fellow, National University of Singapore, June 2006- June 2007.
  3. Postdoctoral Fellow, Nanyang Technological University, Singapore, April 2005- March 2006.
  4. Post-doctoral Fellow, National University of Singapore, July 2003- March 2005.
  5. Research Associate: CSIR-NIIST, Thiruvananthapuram, Kerala, India, February 1997 – June 2003.

Awards & Honors

Recipient of the Research Fellowship under the “Fast Track Scheme for Young scientists” (No. SR/FTP/CS-17/2000) by Science & Engineering Research Council, Department of Science & Technology, Ministry of Science, Government of India, New Delhi- August 2000- June 2003.

Teaching

Organic Synthesis; Medicinal Chemistry; Green Chemistry

Research

Advanced Organic Synthesis; Medicinal Chemistry; Green Chemistry and Materials Science

Our research interests span the disciplines of Synthetic Organic Chemistry and Materials Science with an emphasis on the development of biologically and optically active small molecules and organic-inorganic hybrid materials. We have a longstanding interest in practicing sustainable chemical synthesis (green chemistry). We use advanced synthetic methodologies like Multicomponent Reactions (MCRs) and Click Chemistry to access functional scaffolds such as macrocycles, linear peptidomimetics, and unorthodox non-conjugated fluorescent molecules that can find applications in diagnosis, therapy, imaging, sensors, optoelectronics, and photovoltaics. We are also interested in biomass conversion to obtain platform chemicals that can be further modified to bioactive/fluorescent functional scaffolds.

Research Group Members

Ph.D. Supervision-: 11 (Degree awarded: 10; Thesis submitted: 1)

  1. Shamsiya A.; Thesis Title: Synthesis, Experimental and Computational Studies on Decorated Triazoles as Drug leads, Fluorophores, and Sensors (Thesis submitted -June 2021).
  2. Dr. Shyam Shankar E. P., Thesis Title: Generation of Peptidomimetic Fluorophores via Amenable Chemistry with Multicomponent Reaction (ACMR) Scaffolds (2020).
  3. Dr. Thasnim P. Thesis Title: Applications of Cu (I) Catalyzed Azide-Alkyne Click Cycloaddition for the Development of Fluorescent Probes, Inhibitors, and Ion Sensors (2019).
  4. Dr. Soumya T.V. Thesis Title: Studies on the Development of Peptidomimetic Fluorophores via Copper Catalysed [3+2] Azide-Alkyne Click Cycloaddition Reaction (2018).
  5. Dr. Rajeena Pathoor, Thesis Title: Peptide or Peptidomimetic Randomization of Privileged Structures: A Novel Green Multicomponent Synthetic Route to Drug Leads (2018).
  6. Dr. Jency Mohan T. Thesis Title: MCR-CLICK synthetic strategies for the development of privileged scaffolds based fluorescent inhibitors and multifunctional peptidomimetics (2018).
  7. Dr. Jithin Raj. P. Thesis Title: Studies on the Development of Step-Economic and Cost-Effective Synthesis of Highly Functionalized Peptidomimetic Macrocycles and Dendritic Architectures (2017).
  8. Dr. Arun S., Thesis Title: Studies on the development of one pot multicomponent synthetic protocol for linear and macrocyclic peptidomimetics (2016).
  9. Dr. Biny Balan, Thesis Title: Studies on the development of eco-friendly synthetic protocols to identify bioactive compounds based on clickable MCRs (2014).
  10. Dr. Pramitha P., Thesis Title: Studies on the development of multifunctional peptidomimetic architectures via multicomponent reactions and click chemistry (2013).
  11. Dr. Shinu V.S., Thesis Title: Studies on the development of an eco-friendly multicomponent synthetic approach to Mannich-type N-substituted β-amino acid derivatives (2012).

Ph.D. Co-Supervision- : 1

Dr. Alasdair Brown, Nanyang Technological University- University of Southampton. Thesis title: Lead Halide Perovskite Nanocrystals: Enhancing Commercial Viability for Light-Emitting Applications (2021).

M.Phil. Thesis & M.Sc. Dissertation guidance:

M.Phil. Thesis guidance: 4

  1. Shamsiya A., 2) Muhammed Salim; 3) Soumya T.V.; 4) Arun S.

M.Sc. Dissertation: 4

  1. Likta John; 2) Sreekumar Vellalath; 3) Binita Narayanan; 4) Ambily, M. J.

Projects

  1. “Development of Shape selective and Chemoselective Clay-based catalysts for Fine Chemicals Synthesis” (Thermal and Photochemical): August 2000- June 2003 (Principal Investigator). Funded by SERC (DST), Government of India, under the FastTrack Scheme for Young Scientists (Grant No. SR/FTP/CS-17/2000)    (CSIR-NIIST (Former RRL), Thiruvananthapuram.
  1. “New synthetic methodologies for Industrial Chemicals”, 2000-2003 (Team member).Funded by CSIR- Government of India under the New Millennium Indian Technology Leadership Initiation Programme (NMLITE).
  1. “Perovskite Optoelectronics: Multidimensional Perovskites for High Performance Solution-Processed Light-Emitting Devices,” (Team member). Funded by National Research Foundation (NRF), Singapore under Competitive Research Program, (CRP), 2016-Continuing

Patents

  1. R. Sukumar, K. R. Sabu, M. Lalithambika and D. Bahulayan, An Improved Process for the Synthesis of 4,4’-Diaminodiphenymethane and its Substituted Derivatives, Indian Patent No. 216251, Granted on 11/03/2008

Publications:

  1. Alasdair A. M. Brown, Parth Vashishtha, Thomas J. N. Hooper, Yan Fong Ng, Gautam V. Nutan, Yanan Fang, David Giovanni, Ju Nie Tey, Liudi Jiang, Bahulayan Damodaran, Tze Chien Sum, Suan Hui Pu, Subodh G. Mhaisalkar, and Nripan Mathews, Precise Control of CsPbBr3 Perovskite Nanocrystal Growth at Room Temperature: Size Tunability and Synthetic Insights, Chemistry of Materials, 2021, 33, 2387–2397.
  1. Aranhikkal Shamsiya and Damodaran Bahulayan*, Chromene–triazole-pyrimidine based chemosensor therapeutics for the in vivo and in vitro detection of Fe3+ ions†, New Journal of Chemistry, 2021, 45, 6760-6767.
  1. Alasdair A. M. Brown, Bahulayan Damodaran, Liudi Jiang, Ju Nie Tey , Suan Hui Pu, Nripan Mathews, and Subodh G. Mhaisalkar, Lead Halide Perovskite Nanocrystals: Room Temperature Syntheses toward Commercial Viability, Advanced Energy Materials, 2020, 10, 2001349.
  1. Subodh G. Mhaisalkar, Nripan Mathews, Henk J. Bolink and Damodaran Bahulayan, Advances in Perovskite Optoelectronics: Bridging the Gap Between Laboratory and Fabrication; Advanced Energy Materials, 2020, 10, 2000393.
  1. Kavya S. Keremane, Sateesh Prathapani, Lew Jia Haur, Damodaran Bahulayan, Airody Vasudeva Adhikari, Anish Priyadarshi and Subodh Mhaisalkar, Solvent selection for highly reproducible carbon-based mixed-cation hybrid lead halide perovskite solar cells via adduct approach, Solar Energy, 2020, 199, 761-771.
  1. Raihana Begum, Xin Yu Chin, Bahulayan Damodaran, Thomas J. N. Hooper, Subodh Mhaisalkar and Nripan Mathews; Cesium Lead Halide Perovskite Nanocrystals Prepared by Anion Exchange for Light-Emitting Diodes, ACS Applied Nano Materials, 2020, 3, 1766–1774.
  1. E. P. Shyam Shankar and D. Bahulayan*, Chemistry, Chemical Biology and Photophysics of Certain New Chromene-Triazole-Coumarin Triads as Fluorescent Inhibitors of CDK2 and CDK4 Induced Cancers, New Journal of Chemistry, 2019, 43, 13863-13872.
  1. Alasdair Brown, Thomas Hooper, Sjoerd Veldhuis, Xin Yu Chin, Annalisa Bruno, Parth Vashishtha, Ju Nie Tey, Liudi Jiang, Bahulayan Damodaran, Suan Hui Pu, Subodh Mhaisalkar and Nripan Mathews, Self-assembly of a robust hydrogen-bonded octylphosphonate network on cesium lead bromide perovskite nanocrystals for light-emitting diodes, Nanoscale, 2019, 11, 12370–12380.
  1. Raihana Begum, Xin Yu Chin, Mingjie Li, Bahulayan Damodaran, Tze Chien Sum, Subodh Mhaisalkar, and Nripan Mathews, Stable Sn2+ Doped FAPbI3 Nanocrystals for Near-infrared LED, Chemical Communications, 2019, 55, 5451-5454.
  1. S.S.E. Puthumana and D. Bahulayan*, ICT-Based Blue-Emitting Dual-Functional Probe (Ugi EML BLUE) for Bio-Imaging and Cytotoxic Activities on HeLa Cells, ChemistrySelect, 2019, 4, 5366-5374.
  2. A. Shamsiya and D. Bahulayan*, A Click Strategy for the Synthesis of Fluorescent Pyrimidinone-Triazole Hybrids with CDK2 Selectivity in HeLa and A549 Cell Lines, ChemistrySelect, 2019, 4, 3076-3082.
  1. R. Pathoor, T. Puthiyedath, and D. Bahulayan*, An efficient green diversity oriented synthesis of pyrimidinone and indole appended macrocyclic peptidomimetics, Tetrahedron Letters, 2019, 60, 191-196.
  1. T. Puthiyedath and D. Bahulayan*, A Click Derived Triazole-Coumarin Derivative as Fluorescence On-Off PET Based Sensor for Ca2+and Fe3+Ions, Sensors and Actuators B: Chemical, 2018, 272, 110-117.
  1. K. M. Muhammed Salim, T. M. Koh, D. Bahulayan, P. C. Harikesh, N. F. Jamaludin, B. Febriansyah, A. Bruno, S. Mhaisalkar and N. Mathews, Extended Absorption Window and Improved Stability of Cesium-Based Triple-Cation Perovskite Solar Cells Passivated with Perfluorinated Organics, ACS Energy Letters, 2018, 3, 1068-1076.
  1. R. Pathoor and D. Bahulayan*, MCR-click synthesis, molecular docking and cytotoxicity evaluation of a new series of indole–triazole–coumarin hybrid peptidomimetics, New Journal of Chemistry, 2018, 42, 6810-6816.
  1. S. A. Veldhuis, Y. F. Ng, R. Ahmad, A. Bruno, N. F. Jamaludin, D. Bahulayan, N. Mathews, and S. G. Mhaisalkar, Crown Ethers Enable Room Temperature Synthesized CsPbBr3 Quantum Dots for Light-Emitting Diodes, ACS Energy Letters, 2018, 3, 526–531.
  1. K. M. M. Salim, A. Shamsiya and D. Bahulayan*, Green Synthesis of Fluorescent Peptidomimetic Triazoles from Biomass‐Derived 5‐(Chloromethyl) furfural, ChemistrySelect, 2018, 3, 11141-11146.
  1. S.S.E. Puthumana and D. Bahulayan*, Multicomponent‐Reaction‐(MCR‐) Assisted Synthesis of a Coumarin‐Based Deep Blue Emitter for OLEDs and Related Applications, ChemistrySelect, 2018, 3, 2951– 2957.
  1. T. Puthiyedath and D. Bahulayan*, A click-generated triazole tethered oxazolone-pyrimidinone dyad: a highly selective colorimetric and ratiometric FRET based fluorescent probe for sensing azide ions, Sensors and Actuators B: Chemical, 2017, 239, 1076-1086.
  1. T. Jency Mohan and D. Bahulayan*, Design, synthesis and fluorescence property evaluation of blue emitting triazole-linked chromene peptidomimetics, Molecular diversity, 2017, 21, 585-596.
  2. T. V. Soumya, C. M. Ajmal and D. Bahulayan*, Synthesis of bioactive and fluorescent pyridine-triazole-coumarin peptidomimetics through sequential click-multicomponent reactions,Bioorganic & medicinal chemistry letters, 2017, 27, 450-455.
  1. P. Jithin Raj and D. Bahulayan*, MCR-Click” synthesis of coumarin-tagged macrocycles with large Stokes shift values and cytotoxicity against human breast cancer cell line MCF-7,Tetrahedron Letters, 2017, 58, 2122-2126.
  1. P. Thasnim and D. Bahulayan*, Click-on Fluorescent Triazolyl Coumarin Peptidomimetics as Inhibitors of Human Breast Cancer Cell line MCF-7, New Journal of Chemistry, 2017, 41, 13483-13489.
  1. I. Neogi, A. Bruno, D. Bahulayan, T. W. Goh, B. Ghosh, R. Ganguly, D. Cortecchia, T. C. Sum, C. Soci, N. Mathews, and S. G. Mhaisalkar, Broadband Emitting 2D‐Hybrid Organic Inorganic Perovskite Based on Cyclohexane‐bis (methylammonium) Cation, ChemSusChem, 2017, 10, 3765-3772.
  1. R. Pathoor and D. Bahulayan*, Synthesis of large Stokes shift and narrow emission indole–triazole–carboxamide peptidomimetics via MCR-click strategy, Tetrahedron Letters, 2016, 57, 2360-2366.
  1. S. Bhaumik, S. A. Veldhuis, Y. F. Ng, M. Li, S. K. Muduli, T. C. Sum, D. Bahulayan, S. Mhaisalkar and N. Mathews, Highly stable, luminescent core-shell type methylammonium–octylammonium lead bromide layered perovskite nanoparticles, Chemical Communications, 2016, 52, 7118-7121.
  1. P. Jithin Raj and D Bahulayan*, An efficient click-multicomponent strategy for the diversity oriented synthesis of 15–18 membered macrocyclic peptidomimetic fluorophores, Tetrahedron Letters, 2015, 56, 2451-2455.
  1. T. V. Soumya, P. Thasnim and D. Bahulayan*, Step-economic and cost effective synthesis of coumarin based blue emitting fluorescent dyes, Tetrahedron Letters, 2014, 55, 4643-4647.
  1. B. Balan and D. Bahulayan*, A novel green synthesis of α/β-amino acid functionalized pyrimidinone peptidomimetics using triazole ligation through click-multi-component reactions, Tetrahedron Letters, 2014, 55, 227-231.
  1. B. Balan, and D. Bahulayan*, A Copper‐Catalyzed Multicomponent Reaction and ‘Click Strategy’ for the Stereoselective Synthesis of a New Series of Oxazolone Peptidomimetics with α‐Acylamino Amide and β-Amido Ketone Structures, Helvetica Chimica Acta, 2013, 96, 2251-2266.
  1. B. Balan and D. Bahulayan*, Facile and Rapid Green Route for the Synthesis of Privileged Peptidotriazoles Based on Oxazolonic Acids by Click Fragment Assembly, Bulletin of the Chemical Society of Japan, 2013, 86, 1287-1294.
  1. D. Bahulayan* and S. Arun, An easy two step synthesis of macrocyclic peptidotriazoles via a four-component reaction and copper catalyzed intramolecular azide–alkyne [3+ 2] click cycloaddition, Tetrahedron Letters, 2012, 53, 2850-2855.
  1. D. Bahulayan*, V. S Shinu, P. Pramitha, S. Arun and B. Sheeja, Highly Anti-Selective One-Pot Multicomponent Synthesis of Mannich-Type N-Acylated β-Amino Acid Derivatives by Copper or Sodium Salt Catalysis, Synthetic Communications, 2012, 42, 1162-1176.
  1. P. Pramitha and D. Bahulayan*, Stereoselective synthesis of bio-hybrid amphiphiles of coumarin derivatives by Ugi–Mannich triazole randomization using copper catalyzed alkyne azide click chemistry, Bioorganic & medicinal chemistry letters, 2012, 22, 2598-2603.
  1. V. S. Shinu, P. Pramitha, and D. Bahulayan*, A novel highly stereoselective multi-component synthesis of N-substituted β-amino ketone derivatives using copper (II) phthalocyanine as reusable catalyst, Tetrahedron Letters, 2011, 52, 3110-3115.
  1. V. S Shinu, B. Sheeja, E. Purushothaman, and D. Bahulayan*, An efficient green MCR protocol for the stereoselective synthesis of β-acetamido ketones catalyzed by Selectfluor™, Tetrahedron Letters, 2009, 50, 4838-4843.
  1. D. Bahulayan and H. G. Ang, An Efficient Green Solid Phase Nitration Technique for Synthesis of 4, 10-Dinitro-2,6,8,12-tetraoxa-4,10-diazaisowurtzitane (TEX), In  Theory and Practice of Energetic Materials; Vol.6, Wang, Y., Huang, P., Li, S., Eds..; Science Press USA, 2005, pp 11-14.
  1. D. Bahulayan, C.P. Joshua and H.G. Ang, Liquid Phase and Solid Phase Nitration of Aromatic Compounds: Green Synthetic Routes, NTREM, 2004, 7, 61-67.
  1. D. Bahulayan, S. K. Das and J. Iqbal, Montmorillonite K10 clay: an efficient catalyst for the one-pot stereoselective synthesis of β-acetamido ketones, The Journal of organic chemistry, 2003, 68, 5735-5738.
  1. D. Bahulayan*, L. John and M. Lalithambika, Modified Clays as Efficient Acid-Base Catalyst Systems for Diazotization and Diazocoupling Reactions, Synthetic communications, 2003, 33, 863-869.
  1. D. Bahulayan*, G. Narayan, V. Sreekumar and M. Lalithambika, Natural Bentonite Clay/Dilute HNO3 (40%)—A Mild, Efficient, and Reusable Catalyst/Reagent System for Selective Mono Nitration and Benzylic Oxidations, Synthetic communications, 2002, 32, 3565-3574.
  1. D. Bahulayan, R. Sukumar, K. R. Sabu, and M. Lalithambika, An easy synthesis of 4, 4′-di-aminodiphenylmethanes on natural kaolinites, Green Chemistry, 1999, 1, 191-193.
  1. D. Bahulayan and K. Sreekumar, Chiral polyesters with azobenzene moieties in the main chain, synthesis, and evaluation of nonlinear optical properties, Journal of Materials Chemistry, 1999, 9, 1425-1429.
  1. D. Bahulayan, V. Thomas and K. Sreekumar, Nonlinear optical properties of copolyesters containing azobenzene functionality and chiral groups, Proceedings of SPIE, 1998, 3321, 418-423.

Conferences

  1. ICMAT 2019: 10th International Conference on Materials for Advanced Technologies, 23-28 June 2019, Marina Bay Sands, Singapore.
  1. ICMAT 2017: 9th International Conference on Materials for Advanced Technologies, 18-23 June 2017, Suntec, Singapore.
  1. International Photovoltaic Science and Engineering Conference, PVSEC-26, 24-28 October 2016, Marina Bay Sands, Singapore.
  2. International autumn seminar on Propellants, Explosives, and Pyrotechnics, 25-28, October 2005, Beijing, China.
  3. 11th ACC (11th Asian Chemical Congress), 24-26 August 2005, Seoul, South Korea.
  4. New Trends in Research of Energetic Materials, 7th Seminar, 20-22 April 2004, Pardubice, Czech Republic.

Guest Editor- Journal Special Issues

1. Dual special issues in Advanced Energy Materials and Energy Technology –Topic: “Advances in Perovskite Optoelectronics”, (https://onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1614-6840.Advances-in-Perovskite-Optoelectronics) ,

(https://onlinelibrary.wiley.com/doi/10.1002/aenm.202000393)

2. Dual Special Issues in Energy Technology and ChemSusChem – Topic: "Halide Perovskites for Optoelectronic Applications"

(https://chemistry-europe.onlinelibrary.wiley.com/doi/toc/10.1002/(ISSN)1864-564x.Perovskite)

(https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cssc.201701756)

(https://onlinelibrary.wiley.com/doi/10.1002/ente.201700644)

Erudite Scholar-in-Residence Programmes Organized.

  1. Lecture series by Prof. Alexander Dömling, University of Pittsburgh, the USA on Drug Discovery, January 2011 (Venue: Department of Chemistry, University of Calicut).
  2. Lecture series by Professor Jagadese J. Vittal, the National University of Singapore on Crystal Engineering, February 2011 (Venue: Department of Chemistry, University of Calicut).

Contact Us

Department of Chemistry
University of Calicut
Thenhipallam PO
Malappuram - Kerala, India
PIN 673635
Phone 0494 2407414, 2407413
 
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